What do the lymphoma substages record?
Substage a indicates no systemic signs; substage b indicates systemic illness.
The WHO staging scheme describes how far canine lymphoma extends anatomically; substage a or b separately records whether systemic signs are absent or present.
Stage I is limited to a node or lymphoid tissue in a single organ; stage II is regional nodal involvement, and stage III is generalized nodal disease.
Stage IV adds liver or spleen involvement; stage V includes blood, bone marrow or other organ-system involvement within the scheme.
Substage a indicates no systemic signs; substage b indicates systemic illness. Imaging and assessment of marrow involvement may be needed for staging.
The CHOP treatment discussion addresses a separate question from describing disease distribution.
Substage a indicates no systemic signs; substage b indicates systemic illness.
Vetinuity explains clinical options with journal citations.
The veterinarian diagnoses and prescribes.