● ANSWER
Sourced & dated

What do canine lymphoma stages describe?

The WHO staging scheme describes how far canine lymphoma extends anatomically; substage a or b separately records whether systemic signs are absent or present.

● WHAT'S DOCUMENTED

Read stage as distribution

Stage I is limited to a node or lymphoid tissue in a single organ; stage II is regional nodal involvement, and stage III is generalized nodal disease.

Stage IV adds liver or spleen involvement; stage V includes blood, bone marrow or other organ-system involvement within the scheme.

Keep substage separate from treatment selection

Substage a indicates no systemic signs; substage b indicates systemic illness. Imaging and assessment of marrow involvement may be needed for staging.

The CHOP treatment discussion addresses a separate question from describing disease distribution.

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● SOURCES
  1. 1. Merck: Lymphoma in dogs. Staging; WHO Clinical Staging System table. Checked 2026-10-23.
● FAQ

What do the lymphoma substages record?

Substage a indicates no systemic signs; substage b indicates systemic illness.

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